Open AccessNonimmediate allergic reactions induced by Mesna
Author(s) -
Shimogori Kei,
Araki Makoto,
Shibazaki Shunichi,
Tuda Katuji,
Miura Kohei
Publication year - 2017
Publication title -
journal of general and family medicine
Language(s) - English
Resource type - Journals
ISSN - 2189-7948
DOI - 10.1002/jgf2.79
Subject(s) - mesna , medicine , cyclophosphamide , hemorrhagic cystitis , hypersensitivity reaction , regimen , drug , dermatology , immunology , chemotherapy , pharmacology , ifosfamide , etoposide
Mesna (2‐mercaptoethane sulfonate Na), a drug that alleviates cyclophosphamide ( CYC )‐induced hemorrhagic cystitis, is frequently used to treat cancer and collagen diseases. A 33‐year‐old woman presented with high fever during CYC ‐based induction therapy for systemic lupus erythematosus. Her final diagnosis was mesna‐induced drug hypersensitivity. Although mesna is widely used, allergic reactions are rare. This may be because of misdiagnosis as a primary disease flare‐up, infection, or CYC ‐induced hypersensitivity reaction, which are commonly reported. Thus, accurate diagnosis is important for completion of the CYC ‐based regimen.