Open AccessRAGE in the pathophysiology of skeletal muscle
Author(s) -
Riuzzi Francesca,
Sorci Guglielmo,
Sagheddu Roberta,
Chiappalupi Sara,
Salvadori Laura,
Donato Rosario
Publication year - 2018
Publication title -
journal of cachexia, sarcopenia and muscle
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.803
H-Index - 66
eISSN - 2190-6009
pISSN - 2190-5991
DOI - 10.1002/jcsm.12350
Subject(s) - skeletal muscle , rage (emotion) , glycation , myostatin , wasting , myocyte , medicine , regeneration (biology) , pathophysiology , biology , receptor , endocrinology , neuroscience , microbiology and biotechnology
Emerging evidence suggests that the signalling of the Receptor for Advanced Glycation End products (RAGE) is critical for skeletal muscle physiology controlling both the activity of muscle precursors during skeletal muscle development and the correct time of muscle regeneration after acute injury. On the other hand, the aberrant re‐expression/activity of RAGE in adult skeletal muscle is a hallmark of muscle wasting that occurs in response to ageing, genetic disorders, inflammatory conditions, cancer, and metabolic alterations. In this review, we discuss the mechanisms of action and the ligands of RAGE involved in myoblast differentiation, muscle regeneration, and muscle pathological conditions. We highlight potential therapeutic strategies for targeting RAGE to improve skeletal muscle function.