Open AccessIron deficiency as energetic insult to skeletal muscle in chronic diseases
Author(s) -
Dziegala Magdalena,
Josiak Krystian,
Kasztura Monika,
Kobak Kamil,
Haehling Stephan,
Banasiak Waldemar,
Anker Stefan D.,
Ponikowski Piotr,
Jankowska Ewa
Publication year - 2018
Publication title -
journal of cachexia, sarcopenia and muscle
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.803
H-Index - 66
eISSN - 2190-6009
pISSN - 2190-5991
DOI - 10.1002/jcsm.12314
Subject(s) - skeletal muscle , myopathy , context (archaeology) , medicine , endocrinology , heart failure , oxidative phosphorylation , diabetes mellitus , biology , biochemistry , paleontology
Specific skeletal myopathy constitutes a common feature of heart failure, chronic obstructive pulmonary disease, and type 2 diabetes mellitus, where it can be characterized by the loss of skeletal muscle oxidative capacity. There is evidence from in vitro and animal studies that iron deficiency affects skeletal muscle functioning mainly in the context of its energetics by limiting oxidative metabolism in favour of glycolysis and by alterations in both carbohydrate and fat catabolic processing. In this review, we depict the possible molecular pathomechanisms of skeletal muscle energetic impairment and postulate iron deficiency as an important factor causally linked to loss of muscle oxidative capacity that contributes to skeletal myopathy seen in patients with heart failure, chronic obstructive pulmonary disease, and type 2 diabetes mellitus.