Open AccessDeterminants of muscle preservation in individuals with cerebral palsy across the lifespan: a narrative review of the literature
Author(s) -
Verschuren Olaf,
Smorenburg Ana R.P.,
Luiking Yvette,
Bell Kristie,
Barber Lee,
Peterson Mark D.
Publication year - 2018
Publication title -
journal of cachexia, sarcopenia and muscle
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.803
H-Index - 66
eISSN - 2190-6009
pISSN - 2190-5991
DOI - 10.1002/jcsm.12287
Subject(s) - sarcopenia , ageing , cerebral palsy , narrative review , wasting , muscle mass , muscle atrophy , medicine , atrophy , physical medicine and rehabilitation , psychology , gerontology , pathology , intensive care medicine
In individuals with cerebral palsy (CP), smaller muscle and atrophy are present at young age. Many people with CP also experience a decline in gross motor function as they age, which might be explained by the loss of muscle mass. The clinical observation of muscle wasting has prompted a comparison with sarcopenia in older adults, and the term accelerated musculoskeletal ageing is often used to describe the hallmark phenotype of CP through the lifespan. However, there has been very little research emphasis on the natural history of ageing with CP and even less with respect to the determinants or prevention of muscle loss with CP. Considering the burgeoning interest in the science of muscle preservation, this paper aims to (i) describe the characteristics of accelerated musculoskeletal ageing in people with CP, (ii) describe the pathophysiology of sarcopenia and parallels with CP, and (iii) discuss possible therapeutic approaches, based on established approaches for sarcopenia.