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Objective  The purpose of this article was to investigate whether the combination of urinary beta 2 microglobulin (urinary β 2 ‐ MG ) and procalcitonin ( PCT ) diagnosis could enhance the localization diagnostic precision of pediatric urinary tract infection comparing with single diagnosis.    Methods  A study was conducted in the Nephrology Department of Wuhan women and children's health care centre. This study incorporated 85 participants, including 35 children who were diagnosed as upper urinary tract infection ( UUTI ) with the symptom of fever and 50 children who conducted lower urinary tract infection ( LUTI ). Levels of  PCT  and urinary β 2 ‐ MG  in both  UUTI  and  LUTI  patients were measured and compared.    Results  The level of  PCT  and β 2 ‐ MG  were both significantly higher in  UUTI  group compared with in  LUTI  group.  AUC  of urinary β 2 ‐ MG ROC  (sensitivity of 71.4%, specificity of 90.0%) was significantly smaller than that of  PCT ROC  (sensitivity of 77.1%, specificity of 96.0%) in the single diagnosis. Although in the combined diagnosis, the sensitivity and specificity increased to 88.6% and 98%, respectively.    Conclusions  Both  PCT  and β 2 ‐ MG  could be used to localize the  UTI . Introducing urinary β 2 ‐ MG  into  PCT  diagnosis could increase the sensitivity and specificity of  UTI  lesion diagnosis in clinical practice.

Detection of PCT and urinary β 2 ‐ MG enhances the accuracy for localization diagnosing pediatric urinary tract infection