Open AccessEvaluation of the Relationship Between Microalbuminuria and Urine Ischemia‐Modified Albumin Levels in Patients with Diabetic Nephropathy
Author(s) -
Bilgi Mustafa,
Keser Ahmet,
Katlandur Huseyin,
Sahin Emel,
Kalkan Ali Osman,
Yildiz Murat,
Kiyici Aysel,
Keles Mustafa
Publication year - 2017
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.22058
Subject(s) - microalbuminuria , medicine , albuminuria , diabetic nephropathy , urine , diabetes mellitus , creatinine , urology , proteinuria , ischemia modified albumin , endocrinology , cardiology , gastroenterology , ischemia , kidney , myocardial ischemia
Introduction Ischemia‐modified albumin ( IMA ) is a marker which can be associated with oxidative stress in various ischemic and non‐ischemic processes. Oxidative stress plays roles in diabetes mellitus, its complications and pathogenesis. Serum IMA levels are examined in various clinical events. However, urine IMA levels have not yet been evaluated in diabetic patients. In this study, we aim to examine the relationship between metabolic features and urine microalbuminuria levels of diabetic patients and their urine IMA levels. Materials and Methods There were totally 50 type 2 diabetic patients in the study at the Mevlana University Hospital. Patients with cerebrovascular disease, acute myocardial infarction, hemodialysis patients with end stage chronic renal failure, pulmonary embolism, and malignant disease were excluded from the study. Metabolic features, urine IMA levels and cardiological parameters of patients were evaluated. Results Mean age of patients was 59 ± 9 years, 20 of them (40%) were male and 30 of them (60%) were female. There were six patients with albuminuria value of <0.03 mg/g (normal), there were 39 patients with microalbuminuria value of 0.03–0.3 mg/g and there were five patients with macroalbuminuria of >0.3 mg/g. According to the analysis of patients with microalbuminuria ( n = 39), there was no correlation between IMA levels and numerical demographic data, albuminuria, glucose, HbA1c, lipid profile, creatinine, uric acid, hematological parameters. Discussion Conclusively, there was no relationship between urine IMA levels and microalbuminuria related to the diabetic nephropathy. These findings can be associated with urinary excretion mechanisms of IMA .