Premium
Aggregative Activation in Connection with a Few Reactions Using Transition or Alkali Metal Derivatives as Intermediates
Author(s) -
Caubère Paul
Publication year - 1998
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.199800070
Subject(s) - chemistry , metalation , amide , alkali metal , pyridine , aryl , halide , combinatorial chemistry , base (topology) , transition metal , organic chemistry , catalysis , mathematical analysis , alkyl , mathematics
Abstract Aggregative Activation principles are given. The first application described deals with the preparation of reducing agents used to perform couplings and carbonylations of aryl and hetaryl halides. The second application deals with the preparation of two kind of super bases: sodium amide and butyllithium containing complex bases. The arynic synthesis of indoles is given as an illustration of the use of the first kind of base while the metalation of pyridine derivatives exemplifies the use of the second. In this latter case, a new metalation radical mechanism is proposed.