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The miRNA hsa‐miR‐6515‐3p potentially contributes to lncRNA H19‐mediated‐lung cancer metastasis
Author(s) -
Xu YouZu,
Lin Jian,
Jin YingYing,
Chen Meifang,
Zheng HaiHong,
Feng JiaXi
Publication year - 2019
Publication title -
journal of cellular biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.028
H-Index - 165
eISSN - 1097-4644
pISSN - 0730-2312
DOI - 10.1002/jcb.29006
Subject(s) - microrna , lung cancer , gene knockdown , metastasis , cancer research , epigenetics , biology , cancer , long non coding rna , regulator , phenotype , downregulation and upregulation , medicine , oncology , cell culture , gene , genetics
Aberrant expression of long noncoding RNAs (lncRNAs) contributes to all phenotypes of cancer including metastasis, which is a major cause of death in many advanced malignancies. One particular lncRNA, H19, is found to be a crucial player in cancer progression by modulating multiple microRNAs (miRNAs). In this study, we screened miRNAs possibly associated with H19 using lung carcinoma cell lines and patient with lung cancer tissues, and selected one possible hit, hsa‐miR‐6515‐3p, to perform in vitro functional assays. Its inhibition leads to decreased proliferation and migration of SPC‐A1 lung cancer cells and is in good correlation with H19‐knockdown groups. These results indicate that H19 may be an epigenetic regulator of miR‐6515‐3p, and its dysregulation may contribute to lung cancer progression and metastasis.