Premium
Potent antimicrobial activity of bone cement encapsulating silver nanoparticles capped with oleic acid
Author(s) -
Prokopovich Polina,
Köbrick Mathias,
Brousseau Emmanuel,
Perni Stefano
Publication year - 2015
Publication title -
journal of biomedical materials research part b: applied biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.665
H-Index - 108
eISSN - 1552-4981
pISSN - 1552-4973
DOI - 10.1002/jbm.b.33196
Subject(s) - bone cement , materials science , staphylococcus epidermidis , antimicrobial , acinetobacter baumannii , staphylococcus aureus , oleic acid , polymethyl methacrylate , antibiotics , cement , bone infection , microbiology and biotechnology , bacteria , composite material , polymer , chemistry , pseudomonas aeruginosa , biology , biochemistry , genetics
Abstract Bone cement is widely used in surgical treatments for the fixation for orthopaedic devices. Subsequently, 2–3% of patients undergoing these procedures develop infections that are both a major health risk for patients and a cost for the health service providers; this is also aggravated by the fact that antibiotics are losing efficacy because of the rising resistance of microorganisms to these substances. In this study, oleic acid capped silver nanoparticles (NP) were encapsulated into Poly(methyl methacrylate) (PMMA)‐based bone cement samples at various ratios. Antimicrobial activity against Methicillin Resistant Staphylococcus aureus, S. aureus, Staphylococcus epidermidis, Acinetobacter baumannii was exhibited at NP concentrations as low as 0.05% (w/w). Furthermore, the mechanical properties and cytotoxicity of the bone cement containing these NP were assessed to guarantee that such material is safe to be used in orthopaedic surgical practice. © 2014 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 273–281, 2015.