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Pharmacogeriatrics
Author(s) -
Pucino Frank,
Beck Carol L.,
Seifert Randall L.,
Strommen Gordon L.,
Sheldon Peggy A.,
Silbergleit Inger L.
Publication year - 1985
Publication title -
pharmacotherapy: the journal of human pharmacology and drug therapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.227
H-Index - 109
eISSN - 1875-9114
pISSN - 0277-0008
DOI - 10.1002/j.1875-9114.1985.tb03437.x
Subject(s) - medicine , drug , pharmacodynamics , pharmacokinetics , pharmacotherapy , intensive care medicine , drug reaction , adverse effect , renal function , pharmacology
The elderly comprise one of the fastest growing populations in the United States. By the year 2020, an estimated 45 million will be classified as elderly. Aging is a highly variable process as declines occur in physiologic functions. Alterations in cardiovascular, renal and hepatic function have the greatest effect on drug therapy. All pharmacokinetic and pharmacodynamic variables may be altered by age. Adverse drug reactions, drug interactions and poor compliance are frequent and may further complicate drug therapy. A review of those processes that commonly influence pharmacologic response and patient compliance to drug therapy is appropriate.