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Role of microRNAs in Staphylococcus aureus infection: Potential biomarkers and mechanism
Author(s) -
Mirzaei Rasoul,
Mohammadzadeh Rokhsareh,
Mirzaei Hamed,
Sholeh Mohammad,
Karampoor Sajad,
Abdi Milad,
Alikhani Mohammad Yousef,
Kazemi Sima,
Ahmadyousefi Yaghoub,
Jalalifar Saba,
Yousefimashouf Rasoul
Publication year - 2020
Publication title -
iubmb life
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.132
H-Index - 113
eISSN - 1521-6551
pISSN - 1521-6543
DOI - 10.1002/iub.2325
Subject(s) - staphylococcus aureus , innate immune system , immune system , biology , microbiology and biotechnology , microrna , pathogen , pneumonia , acquired immune system , immunology , endocarditis , mechanism (biology) , bacteremia , staphylococcal infections , bacteria , medicine , gene , antibiotics , genetics , philosophy , surgery , epistemology
Abstract Staphylococcus aureus is known as a common pathogen that colonizes 30% of healthy humans. Additionally, this bacterium can cause a number of serious infections, that is, endocarditis, bacteremia, pneumonia, wound, skin infections, and tissue abscesses. A variety of cellular and molecular pathways and targets are involved in response against S. aureus . Among them, microRNAs (miRNAs) have crucial roles in response against S. aureus . In this regard, it has been shown that these molecules exert their regulatory roles via modulating a wide range of events, such as inflammatory reactions, host innate, and adaptive immunity. Current works have provided insight into the crucial involvement of miRNAs in immune defense toward Staphylococcal infections. Herein, we highlighted the current findings on the deregulation of different miRNAs in S. aureus ‐infected cells . Moreover, we summarized the mechanisms and targets of miRNAs in S. aureus infections.