Open AccessRapid progression of recurrent disease in a patient with renal cell carcinoma with vaginal metastasis
Author(s) -
Hisano Mizuki,
Kato Renpei,
Itamochi Hiroaki,
Matsuura Tomohiko,
Maekawa Shigekatsu,
Kato Yoichiro,
Kanehira Mitsugu,
Takata Ryo,
Baba Tsukasa,
Obara Wataru
Publication year - 2020
Publication title -
iju case reports
Language(s) - English
Resource type - Journals
ISSN - 2577-171X
DOI - 10.1002/iju5.12179
Subject(s) - medicine , sunitinib , nivolumab , renal cell carcinoma , metastasis , nephrectomy , clear cell carcinoma , carcinoma , clear cell renal cell carcinoma , immunohistochemistry , oncology , pathology , kidney , cancer , immunotherapy
We report a rare case of renal cell carcinoma with vaginal metastasis that recurred with rapid progression and was resistant to sunitinib and nivolumab. Case presentation A 68‐year‐old woman presented with renal cell carcinoma and vaginal metastasis. Multiple lung metastasis appeared 3 months after simultaneous radical nephrectomy and hysterectomy with vaginal resection. Despite the treatment with sunitinib and nivolumab, the patient died 7 months after surgery. Immunohistochemical staining of primary and metastatic tumor specimens was CD8 and programmed death ligand‐1 negative. Conclusion Although vaginal metastasis of renal cell carcinoma is rare, lack of CD8 and programmed death ligand‐1 expression may cause nivolumab resistance and may be useful markers in patients with metastatic renal cell carcinoma.