Open AccessGATA‐3 expression in primary pure choriocarcinoma of the bladder
Author(s) -
Shinohara Mayuka,
Shin Toshitaka,
Daa Tsutomu,
Mimata Hiromitsu
Publication year - 2020
Publication title -
iju case reports
Language(s) - English
Resource type - Journals
ISSN - 2577-171X
DOI - 10.1002/iju5.12151
Subject(s) - immunostaining , choriocarcinoma , cystoscopy , medicine , pathology , cystectomy , asymptomatic , carcinoma , immunohistochemistry , bladder cancer , urology , cancer , alternative medicine
Primary pure choriocarcinoma of the bladder is extremely rare and should be distinguished from urothelial carcinoma. GATA‐3 is a zinc finger transcription factor and a known sensitive immunostaining marker for urothelial carcinoma. However, its accuracy in the detection of urothelial carcinoma is moderate and it is also an important factor in trophoblast differentiation. Case presentation A 78‐year‐old man presented with asymptomatic gross hematuria for 6 months. Cystoscopy and clinical imaging revealed local bladder carcinoma. He underwent a radical cystectomy and histological diagnosis revealed pure choriocarcinoma (pT2aN0M0) with positive immunostaining, indicating GATA‐3 was present. Systemic chemotherapy could not be applied due to his poor general condition, and he died 7 months after surgery. Conclusion We reported the first case of pure choriocarcinoma of the bladder, which showed positive immunostaining results indicating the presence of GATA‐3.