Open AccessMalignant melanoma of the male urethra with increased 5‐ S ‐cysteinyldopa: A case report
Author(s) -
Aoki Yusuke,
Soma Takahiko,
Nakamura Yuki,
Fukui Naotaka,
Sakai Yasuyuki,
Kageyama Yukio
Publication year - 2019
Publication title -
iju case reports
Language(s) - English
Resource type - Journals
ISSN - 2577-171X
DOI - 10.1002/iju5.12086
Subject(s) - dysuria , medicine , melanoma , urethra , penectomy , biopsy , urology , surgery , pathology , penis , urinary system , penile cancer , cancer research
We herein present a case of malignant melanoma of the male urethra with an increased serum 5‐ S ‐cysteinyldopa concentration. Case presentation A 77‐year‐old man visited our hospital complaining dysuria and a dark brown mass protruding from the external urethral meatus. His serum 5‐ S ‐ cysteinyldopa concentration was elevated beyond the upper limit of the reference range. Biopsy of the tumor was performed, and the histological diagnosis was malignant melanoma. He underwent total penectomy, and the serum 5‐ S ‐ cysteinyldopa concentration was normalized. He remained alive without evidence of locoregional recurrence or distant metastases for 6 months after surgery. Conclusion Malignant melanoma of the male urethra is uncommon. The prognosis is favorable if it is detected in its early stages. This case report suggests that measurement of the serum concentration of 5‐ S ‐ cysteinyldopa , a melanin metabolite, is useful for early diagnosis of male urethral melanoma.