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Detection of oncornavirus‐like particles in HeLa cells. I. Fine structure and comparative morphological classification
Author(s) -
Gelderblom Hans,
Bauer Heinz,
Ogura Hajime,
Wigand Reinhard,
Fischer Anna B.
Publication year - 1974
Publication title -
international journal of cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.475
H-Index - 234
eISSN - 1097-0215
pISSN - 0020-7136
DOI - 10.1002/ijc.2910130212
Subject(s) - hela , budding , virology , virus , biology , haplorhini , cell , microbiology and biotechnology , biophysics , biochemistry
Abstract Oncornavirus‐like particles have been consistently observed over a period of 3 years in HeLa cells obtained from several laboratories. The particles mature by budding, in that previously fully assembled A‐type‐like particles are enveloped by the protruding cell membrane with subsequent release of the virion. When compared morphologically to B‐ and C‐type particles, distinct differences were observed; however, the HeLa particles closely resemble two primate viruses, namely the Mason‐Pfizer monkey virus and a recently discovered virus derived from human brain cells. HeLa particles demonstrate a narrow host range. Thus a new morphological group of viruses emerges that might be specific for primates.