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Neue β‐Lactam‐Antibiotika. Zur Funktionalisierung von 3‐Hydroxy‐3‐cephem‐4‐carbonsäureestern durch die Wittig ‐Reaktion. Modifikationen von Antibiotika. 16. Mitteilung [1]
Author(s) -
Scartazzini Riccardo
Publication year - 1977
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19770600508
Subject(s) - chemistry , wittig reaction , lactam , cephem , derivative (finance) , antibiotics , stereochemistry , organic chemistry , carboxylic acid , biochemistry , financial economics , economics
New β‐lactam antibiotics. Functionalisation of 3‐hydroxy‐3‐cephem‐4‐carboxylic esters through the Wittig reaction The 3‐hydroxy‐ceph‐3‐em‐esters 1a, b reacted smoothly with stabilized phosphor‐ylids to give a series of derivatives which were converted into the microbiologically active acids 14a, c, 15c and 20 by known procedures. The synthesis of the amides 23, 24, 26 and of the ester 28 from the 3‐carboxymethyl‐derivative 19 is also reported.