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Eine neuartige radikalinduzierte intramolekulare Gruppenübertragung . Synthese von 18‐Cyan‐corticosteroiden. Über Steroide, 225. Mitteilung
Author(s) -
Kalvoda J.,
Botta L.
Publication year - 1972
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19720550205
Subject(s) - chemistry , nitrile , stereochemistry , brucine , medicinal chemistry , strychnine , organic chemistry , biochemistry
Abstract A radical‐induced transfer of an entire functional group in steroid derivatives is described: the photolysis of an 11β‐nitrite function initiates the migration of a nitrile group from the 20‐ to the 18‐position. The reaction was used for the synthesis of new 18‐cyano‐corticoids.