Open AccessInterferon Type I Regulates Inflammasome Activation and High Mobility Group Box 1 Translocation in Hepatocytes During Ehrlichia ‐Induced Acute Liver Injury
Author(s) -
Kader Muhamuda,
El Andaloussi Abdeljabar,
Vorhaour Jennie,
Tamama Kenichi,
Nieto Natalia,
Scott Melanie J.,
Ismail Nahed
Publication year - 2021
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1608
Subject(s) - biology , chemokine , caspase 1 , inflammasome , innate immune system , immunology , microbiology and biotechnology , inflammation , immune system
IFN‐I signaling exacerbate liver pathology and contribute to sepsis following fatal Ehrlichia infection by promoting Ehrlichia replication and mediating detrimental inflammasome activation.