Open AccessIs Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?
Author(s) -
Miura Kouichi,
Yamamoto Hironori
Publication year - 2019
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1366
Subject(s) - steatohepatitis , mapk/erk pathway , protein kinase a , microbiology and biotechnology , ask1 , mitogen activated protein kinase kinase , mitogen activated protein kinase , regulator , map kinase kinase kinase , phosphatase , signal transduction , kinase , chemistry , biology , phosphorylation , biochemistry , medicine , fatty liver , disease , gene
While intensive investigations on MAPK signaling pathways discovered their critical functions in the development of obesity as well as steatohepatitis, the studies have also suggested their complexity. MKP5, a negative regulator of MAPK signaling, contributes to the improvement of steatohepatitis.