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While intensive investigations on MAPK signaling pathways discovered their critical functions in the development of obesity as well as steatohepatitis, the studies have also suggested their complexity. MKP5, a negative regulator of MAPK signaling, contributes to the improvement of steatohepatitis.

Is Mitogen‐Activated Protein Kinase Phosphatase 5 a Solution to the Puzzle of the Mitogen‐Activated Protein Kinase Signal in Steatohepatitis?