Open AccessA Pilot Clinical Trial of Nitazoxanide in the Treatment of Chronic Hepatitis B
Author(s) -
Rossignol JeanFrançois,
Bréchot Christian
Publication year - 2019
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1339
Subject(s) - nitazoxanide , chronic hepatitis , medicine , clinical trial , virology , intensive care medicine , virus
Chronic infection by the hepatitis B virus (HBV) has remained a major public health problem. To achieve an HBV cure, we will likely need to combine antivirals with different viral targets as well as immunotherapy. Here, we report data from a pilot proof‐of‐concept clinical trial of nitazoxanide in treating chronic hepatitis B. Conclusion: Nitazoxanide offers novel mechanisms of antiviral activity, and it would be interesting to evaluate the potential of combining nitazoxanide with oral nucleos(t)ide analogues.