Open AccessIntestinal Lipolysis Mitigates Nonalcoholic Fatty Liver Disease: New Roles for Carboxylesterase 2c in the Intestine
Author(s) -
Pimienta Michael,
Beletsky Alexander,
Seki Ekihiro
Publication year - 2019
Publication title -
hepatology communications
Language(s) - English
Resource type - Journals
ISSN - 2471-254X
DOI - 10.1002/hep4.1318
Subject(s) - nonalcoholic fatty liver disease , insulin resistance , lipogenesis , medicine , fatty liver , type 2 diabetes , endocrinology , type 2 diabetes mellitus , obesity , diabetes mellitus , biology , bioinformatics , disease , lipid metabolism
The most important argument of this study is that modulation of intestinal lipid metabolism by enhancing intestinal Ces2c expression has the potential to affect hepatic and systemic lipid metabolism, regulating the development of NAFLD and systemic insulin resistance.