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Serum lactate dehydrogenase is a predictive biomarker in patients with oropharyngeal cancer undergoing radiotherapy: Retrospective study on predictive factors
Author(s) -
Uehara Takuya,
Doi Hiroshi,
Ishikawa Kazuki,
Inada Masahiro,
Tatsuno Saori,
Wada Yutaro,
Oguma Yasuo,
Kawakami Hisato,
Nakamatsu Kiyoshi,
Hosono Makoto,
Nishimura Yasumasa
Publication year - 2021
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.26814
Subject(s) - medicine , lactate dehydrogenase , oncology , radiation therapy , multivariate analysis , retrospective cohort study , univariate analysis , gastroenterology , cancer , stage (stratigraphy) , biomarker , biology , paleontology , biochemistry , enzyme
Background The present study aimed to evaluate the prognostic factors in human papillomavirus (HPV)‐positive and HPV‐negative oropharyngeal cancer (OPC) treated with definitive radiotherapy. Methods We retrospectively evaluated 101 patients with OPC who underwent definitive radiotherapy between 2008 and 2018. Results The median follow‐up period of the surviving patients was 68 months (range, 8–164 months). The 5‐year overall survival rate was 69.8%. Univariate analyses revealed that poor survival was associated with male sex, smoking ≥30 pack‐years, Eastern Cooperative Oncology Group performance status ≥1, tumor‐node‐metastasis (TNM) stage III‐IV (8th edition), HPV‐negativity, serum lactate dehydrogenase (LDH) ≥202, C‐reactive protein/albumin ratio ≥0.15, and lymphocyte‐to‐monocyte ratio <2.90. In multivariate analyses, poor survival was independently correlated with smoking ≥30 pack‐years ( p < 0.01) and LDH ≥202 ( p = 0.02). Conclusions The present study suggested that high LDH levels predicted poor survival after definitive radiotherapy for patients with both HPV‐positive and HPV‐negative OPC.