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Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults
Author(s) -
Boon Eline,
van der Graaf Winette T. A.,
Gelderblom Hans,
Tesselaar Margot E. T.,
van Es Robert J. J.,
Oosting Sjoukje F.,
de Bree Remco,
van Meerten Esther,
Hoeben Ann,
Smeele Ludi E.,
Willems Stefan M.,
Witjes Max J. H.,
Buter Jan,
Baatenburg de Jong Robert J.,
Flucke Uta E.,
Peer Petronella G. M.,
Bovée Judith V. M. G.,
Van Herpen Carla M. L.
Publication year - 2017
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.24556
Subject(s) - medicine , osteosarcoma , chemotherapy , head and neck , hazard ratio , adjuvant chemotherapy , univariate analysis , head and neck cancer , surgery , radiation therapy , oncology , multivariate analysis , cancer , confidence interval , pathology , breast cancer
Background There is an ongoing debate about the value of (neo‐)adjuvant chemotherapy in high‐ and intermediate‐grade osteosarcoma of the head and neck. Methods All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed. Results We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5‐year overall survival (OS) was 55%. In 50 patients with surgically resected high‐ or intermediate‐grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively). Conclusion In patients younger than 75 years of age with surgically resected high‐ and intermediate‐grade osteosarcoma of the head and neck, treatment with (neo‐)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo‐)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140–146, 2017