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Salivary duct carcinoma with rhabdoid features: Report of 2 cases with immunohistochemical and ultrastructural analyses
Author(s) -
Kusafuka Kimihide,
Onitsuka Tetsuro,
Muramatsu Koji,
Miki Tomoko,
Murai Chika,
Suda Toshihito,
Fuke Tomohito,
Kamijo Tomoyuki,
Iida Yoshiyuki,
Nakajima Takashi
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23466
Subject(s) - salivary duct carcinoma , pathology , carcinoma ex pleomorphic adenoma , pleomorphic adenoma , carcinoma , immunohistochemistry , adenoma , adenocarcinoma , salivary gland , medicine , biology , cancer
Background Salivary duct carcinoma with rhabdoid features is extremely rare. Methods We report 2 cases of salivary duct carcinoma with rhabdoid features treated at our institution. Results Case 1 was a 44‐year‐old Japanese man who had swelling in the left parotid region. This tumor consisted of residual pleomorphic adenoma and widely invasive carcinoma, which showed a diffuse growth pattern by atypical rhabdoid cells. Case 2 was a 66‐year‐old Japanese man who had swelling of the right cervical region. This submandibular tumor was also composed of both residual pleomorphic adenoma region and invasive adenocarcinoma components, whereas some metastatic lesions were purely composed of rhabdoid cells. Such cells were strongly and diffusely positive for cytokeratins (CKs), gross cystic disease fluid protein‐15 (GCDFP), and androgen receptor (AR). Case 1 was also positive for Her‐2 and p53. Conclusion Both patients were diagnosed with carcinoma ex pleomorphic adenoma and their carcinomatous components were composed of salivary duct carcinoma with rhabdoid features, which is a highly aggressive tumor, similar to salivary duct carcinoma. © 2013 The Authors. Head & Neck published by Wiley Periodicals, Inc. Head Neck 36 : E28–E35, 2014