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Reproducible resting‐state functional connectivity (rsFC) patterns and their alterations play an increasing role in neuropsychiatric research. Studies that limit the analysis of metabolites and  rsFC strengths  to a predefined canonical network suggest that the  rsFC strength  positively correlates with the local glutamate (Glu) levels and negatively correlates with the gamma‐aminobutyric acid (GABA) levels. The contribution of regional neurotransmitter activity to  rsFC strengths  from a given seed to the whole‐brain remains unclear. In this study, 121 healthy participants (50 female/71 male) underwent multimodal resting‐state functional magnetic resonance imaging (rsfMRI) and magnetic resonance spectroscopy (MRS) at 7 T, allowing for acquisition of multiple, neuroanatomically well‐defined MRS voxels in the same session. We examined the association between rsFC and local neurotransmitter levels in the pregenual anterior cingulate cortex (pgACC) and the anterior mid‐cingulate cortex (aMCC) by varying  rsFC strengths  at the whole‐brain level. Our results showed that both glutamatergic and GABAergic  edge weights  (defined as the across‐participants partial correlation coefficients between the local metabolite levels and the rsFC of the seed region to each target parcel) were positively correlated with the  rsFC strengths  in the pgACC and negatively correlated with the  rsFC strengths  in the aMCC. The region‐dependent directionality of associations may indicate that region‐specific microscale properties, such as neurotransmitter receptor architecture, modulate the interaction between brain regions at the macroscale level.

human brain mapping

The differential association between local neurotransmitter levels and whole‐brain resting‐state functional connectivity in two distinct cingulate cortex subregions