Open AccessLeft parietal involvement in motion sickness susceptibility revealed by multimodal magnetic resonance imaging
Author(s) -
Sakai Hiroyuki,
Harada Takumi,
Larroque Stephen K.,
Demertzi Athena,
Sugawara Tomoko,
Ito Taeko,
Wada Yoshiro,
Fukunaga Masaki,
Sadato Norihiro,
Laureys Steven
Publication year - 2022
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25710
Subject(s) - motion sickness , neuroscience , white matter , resting state fmri , parietal lobe , intraparietal sulcus , functional connectivity , functional magnetic resonance imaging , vestibular system , psychology , cingulum (brain) , magnetic resonance imaging , medicine , fractional anisotropy , psychiatry , radiology
Susceptibility to motion sickness varies greatly across individuals. However, the neural mechanisms underlying this susceptibility remain largely unclear. To address this gap, the current study aimed to identify the neural correlates of motion sickness susceptibility using multimodal MRI. First, we compared resting‐state functional connectivity between healthy individuals who were highly susceptible to motion sickness ( N = 36) and age/sex‐matched controls who showed low susceptibility ( N = 36). Seed‐based analysis revealed between‐group differences in functional connectivity of core vestibular regions in the left posterior Sylvian fissure. A data‐driven approach using intrinsic connectivity contrast found greater network centrality of the left intraparietal sulcus in high‐ rather than in low‐susceptible individuals. Moreover, exploratory structural connectivity analysis uncovered an association between motion sickness susceptibility and white matter integrity in the left inferior fronto‐occipital fasciculus. Taken together, our data indicate left parietal involvement in motion sickness susceptibility.