Open AccessTemporal variability of regional intrinsic neural activity in drug‐naïve patients with obsessive–compulsive disorder
Author(s) -
Liu Jing,
Bu Xuan,
Hu Xinyu,
Li Hailong,
Cao Lingxiao,
Gao Yingxue,
Liang Kaili,
Zhang Lianqing,
Lu Lu,
Hu Xinyue,
Wang Yanlin,
Gong Qiyong,
Huang Xiaoqi
Publication year - 2021
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25465
Subject(s) - cuneus , fusiform gyrus , neuroscience , psychology , dorsolateral prefrontal cortex , inferior parietal lobule , anterior cingulate cortex , lingual gyrus , drug naïve , occipital lobe , prefrontal cortex , audiology , medicine , functional magnetic resonance imaging , precuneus , psychiatry , cognition , drug
Obsessive–compulsive disorder (OCD) displays alterations in regional brain activity represented by the amplitude of low‐frequency fluctuation (ALFF), but the time‐varying characteristics of this local neural activity remain to be clarified. We aimed to investigate the dynamic changes of intrinsic brain activity in a relatively large sample of drug‐naïve OCD patients using univariate and multivariate analyses. We applied a sliding‐window approach to calculate the dynamic ALFF (dALFF) and compared the difference between 73 OCD patients and age‐ and sex‐matched healthy controls (HCs). We also utilized multivariate pattern analysis to determine whether dALFF could differentiate OCD patients from HCs at the individual level. Compared with HCs, OCD patients exhibited increased dALFF mainly within regions of the cortical–striatal–thalamic–cortical (CSTC) circuit, including the bilateral dorsal anterior cingulate cortex, medial prefrontal cortex and striatum, and right dorsolateral prefrontal cortex (dlPFC). Decreased dALFF was identified in the bilateral inferior parietal lobule (IPL), posterior cingulate cortex, insula, fusiform gyrus, and cerebellum. Moreover, we found negative correlations between illness duration and dALFF values in the right IPL and between dALFF values in the left cerebellum and Hamilton Depression Scale scores. Furthermore, dALFF can distinguish OCD patients from HCs with the most discriminative regions located in the IPL, dlPFC, middle occipital gyrus, and cuneus. Taken together, in the current study, we demonstrated a characteristic pattern of higher variability of regional brain activity within the CSTC circuits and lower variability in regions outside the CSTC circuits in drug‐naïve OCD patients.