Open AccessInterrelations between dopamine and serotonin producing sites and regions of the default mode network
Author(s) -
Cruz Feliberto,
Wagner Gerd,
Schumann Andy,
Suttkus Stefanie,
Güllmar Daniel,
Reichenbach Jürgen R.,
Bär KarlJürgen
Publication year - 2021
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25264
Subject(s) - monoaminergic , default mode network , neuroscience , dopamine , functional magnetic resonance imaging , midbrain , brainstem , resting state fmri , psychology , serotonin , biology , medicine , central nervous system , receptor
Recent functional magnetic resonance imaging (fMRI) studies showed that blood oxygenation level‐dependent (BOLD) signal fluctuations in the default mode network (DMN) are functionally tightly connected to those in monoaminergic nuclei, producing dopamine (DA), and serotonin (5‐HT) transmitters, in the midbrain/brainstem. We combined accelerated fMRI acquisition with spectral Granger causality and coherence analysis to investigate causal relationships between these areas. Both methods independently lead to similar results and confirm the existence of a top‐down information flow in the resting‐state condition, where activity in core DMN areas influences activity in the neuromodulatory centers producing DA/5‐HT. We found that latencies range from milliseconds to seconds with high inter‐subject variability, likely attributable to the resting condition. Our novel findings provide new insights into the functional organization of the human brain.