Open AccessPhonological and surface dyslexia in individuals with brain tumors: Performance pre‐, intra‐, immediately post‐surgery and at follow‐up
Author(s) -
Tomasino Barbara,
Ius Tamara,
Skrap Miran,
Luzzatti Claudio
Publication year - 2020
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25176
Subject(s) - supramarginal gyrus , arcuate fasciculus , dyslexia , superior longitudinal fasciculus , psychology , precentral gyrus , insula , superior temporal gyrus , neuropsychology , middle frontal gyrus , audiology , neuroscience , reading (process) , medicine , diffusion mri , tractography , magnetic resonance imaging , fractional anisotropy , cognition , functional magnetic resonance imaging , radiology , political science , law
We address existing controversies regarding neuroanatomical substrates of reading‐aloud processes according to the dual‐route processing models, in this particular instance in a series of 49 individuals with brain tumors who performed several reading tasks of real‐time neuropsychological testing during surgery (low‐ to high‐grade cerebral neoplasms involving the left hemisphere). We explored how reading abilities in individuals with brain tumors evolve during and after surgery for a brain tumor, and we studied the reading performance in a sample of 33 individuals in a 4‐month follow‐up after surgery. Impaired reading performance was seen pre‐surgery in 7 individuals with brain tumors, intra‐surgery in 18 individuals, at immediate post‐surgery testing in 26 individuals, and at follow‐up in 5 individuals. We classified their reading disorders according to operational criteria for either phonological or surface dyslexia. Neuroimaging results are discussed within the theoretical framework of the dual‐route model of reading. Lesion‐mask subtraction analyses revealed that areas selectively related with phonological dyslexia were located—along with the left hemisphere dorsal stream—in the Rolandic operculum, the inferior frontal gyrus, the precentral gyrus, the supramarginal gyrus, the insula (and/or the underlying external capsule), and parts of the superior longitudinal fasciculus, whereas lesions related to surface dyslexia involved the ventral stream, that is, the left middle and inferior temporal gyrus and parts of the left inferior longitudinal fasciculus.