Open AccessConsortium neuroscience of attention deficit/hyperactivity disorder and autism spectrum disorder: The ENIGMA adventure
Author(s) -
Hoogman Martine,
Rooij Daan,
Klein Marieke,
Boedhoe Premika,
Ilioska Iva,
Li Ting,
Patel Yash,
Postema Merel C.,
ZhangJames Yanli,
Anagnostou Evdokia,
Arango Celso,
Auzias Guillaume,
Banaschewski Tobias,
Bau Claiton H. D.,
Behrmann Marlene,
Bellgrove Mark A.,
Brandeis Daniel,
Brem Silvia,
Busatto Geraldo F.,
Calderoni Sara,
Calvo Rosa,
Castellanos Francisco X.,
Coghill David,
Conzelmann Annette,
Daly Eileen,
Deruelle Christine,
Dinstein Ilan,
Durston Sarah,
Ecker Christine,
Ehrlich Stefan,
Epstein Jeffery N.,
Fair Damien A.,
Fitzgerald Jacqueline,
Freitag Christine M.,
Frodl Thomas,
Gallagher Louise,
Grevet Eugenio H.,
Haavik Jan,
Hoekstra Pieter J.,
Janssen Joost,
Karkashadze Georgii,
King Joseph A.,
Konrad Kerstin,
Kuntsi Jonna,
Lazaro Luisa,
Lerch Jason P.,
Lesch KlausPeter,
Louza Mario R.,
Luna Beatriz,
Mattos Paulo,
McGrath Jane,
Muratori Filippo,
Murphy Clodagh,
Nigg Joel T.,
OberwellandWeiss Eileen,
O'Gorman Tuura Ruth L.,
O'Hearn Kirsten,
Oosterlaan Jaap,
Parellada Mara,
Pauli Paul,
Plessen Kerstin J.,
RamosQuiroga J. Antoni,
Reif Andreas,
Reneman Liesbeth,
Retico Alessandra,
Rosa Pedro G. P.,
Rubia Katya,
Shaw Philip,
Silk Tim J.,
Tamm Leanne,
Vilarroya Oscar,
Walitza Susanne,
Jahanshad Neda,
Faraone Stephen V.,
Francks Clyde,
Heuvel Odile A.,
Paus Tomas,
Thompson Paul M.,
Buitelaar Jan K.,
Franke Barbara
Publication year - 2022
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.25029
Subject(s) - neuroimaging , autism spectrum disorder , attention deficit hyperactivity disorder , psychology , neuroscience , modalities , resting state fmri , neurodevelopmental disorder , autism , clinical psychology , psychiatry , social science , sociology
Neuroimaging has been extensively used to study brain structure and function in individuals with attention deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) over the past decades. Two of the main shortcomings of the neuroimaging literature of these disorders are the small sample sizes employed and the heterogeneity of methods used. In 2013 and 2014, the ENIGMA‐ADHD and ENIGMA‐ASD working groups were respectively, founded with a common goal to address these limitations. Here, we provide a narrative review of the thus far completed and still ongoing projects of these working groups. Due to an implicitly hierarchical psychiatric diagnostic classification system, the fields of ADHD and ASD have developed largely in isolation, despite the considerable overlap in the occurrence of the disorders. The collaboration between the ENIGMA‐ADHD and ‐ASD working groups seeks to bring the neuroimaging efforts of the two disorders closer together. The outcomes of case–control studies of subcortical and cortical structures showed that subcortical volumes are similarly affected in ASD and ADHD, albeit with small effect sizes. Cortical analyses identified unique differences in each disorder, but also considerable overlap between the two, specifically in cortical thickness. Ongoing work is examining alternative research questions, such as brain laterality, prediction of case–control status, and anatomical heterogeneity. In brief, great strides have been made toward fulfilling the aims of the ENIGMA collaborations, while new ideas and follow‐up analyses continue that include more imaging modalities (diffusion MRI and resting‐state functional MRI), collaborations with other large databases, and samples with dual diagnoses.