Open AccessGlobal resting‐state functional connectivity of neural oscillations in tinnitus with and without hearing loss
Author(s) -
Demopoulos Carly,
Duong Xuan,
Hinkley Leighton B.,
Ranasinghe Kamalini G.,
Mizuiri Danielle,
Garrett Coleman,
Honma Susanne,
HendersonSabes Jennifer,
Findlay Anne,
RacineBelkoura Caroline,
Cheung Steven W.,
Nagarajan Srikantan S.
Publication year - 2020
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24981
Subject(s) - tinnitus , audiology , hearing loss , functional connectivity , resting state fmri , neuroscience , psychology , auditory cortex , medicine
This study examined global resting‐state functional connectivity of neural oscillations in individuals with chronic tinnitus and normal and impaired hearing. We tested the hypothesis that distinct neural oscillatory networks are engaged in tinnitus with and without hearing loss. In both tinnitus groups, with and without hearing loss, we identified multiple frequency band‐dependent regions of increased and decreased global functional connectivity. We also found that the auditory domain of tinnitus severity, assayed by the Tinnitus Functional Index, was associated with global functional connectivity in both auditory and nonauditory regions. These findings provide candidate biomarkers to target and monitor treatments for tinnitus with and without hearing loss.