Open AccessLongitudinal trajectory of Amyloid‐related hippocampal subfield atrophy in nondemented elderly
Author(s) -
Zhang Liwen,
Mak Elijah,
Reilhac Anthonin,
Shim Hee Y.,
Ng Kwun K.,
Ong Marcus Q. W.,
Ji Fang,
Chong Eddie J. Y.,
Xu Xin,
Wong Zi X.,
Stephenson Mary C.,
Venketasubramanian Narayanaswamy,
Tan Boon Y.,
O'Brien John T.,
Zhou Juan H.,
Chen Christopher L.H.
Publication year - 2020
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24928
Subject(s) - atrophy , hippocampal formation , dementia , neuroscience , psychology , alzheimer's disease , episodic memory , longitudinal study , cognitive decline , pittsburgh compound b , cognition , medicine , pathology , disease , cognitive impairment
Hippocampal atrophy and abnormal β‐Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ‐associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET‐Aβ in AD‐vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto‐segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of Aβ‐related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher Aβ correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal‐to‐widespread trajectory of Aβ‐associated hippocampal subfield atrophy over disease progression in nondemented elderly.