Open AccessEvaluation of the spatial variability in the major resting‐state networks across human brain functional atlases
Author(s) -
Doucet Gaelle E.,
Lee Won Hee,
Frangou Sophia
Publication year - 2019
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.24722
Subject(s) - resting state fmri , default mode network , precuneus , human brain , voxel , neuroscience , salience (neuroscience) , functional connectivity , spatial normalization , brain mapping , connectome , cartography , computer science , pattern recognition (psychology) , artificial intelligence , psychology , functional magnetic resonance imaging , geography
The human brain is intrinsically organized into resting‐state networks (RSNs). Currently, several human brain functional atlases are used to define the spatial constituents of these RSNs. However, there are significant concerns about interatlas variability. In response, we undertook a quantitative comparison of the five major RSNs (default mode [DMN], salience, central executive, sensorimotor, and visual networks) across currently available brain functional atlases ( n = 6) in which we demonstrated that (a) similarity between atlases was modest and positively linked to the size of the sample used to construct them; (b) across atlases, spatial overlap among major RSNs ranged between 17 and 76% (mean = 39%), which resulted in variability in their functional connectivity; (c) lower order RSNs were generally spatially conserved across atlases; (d) among higher order RSNs, the DMN was the most conserved across atlases; and (e) voxel‐wise flexibility (i.e., the likelihood of a voxel to change network assignment across atlases) was high for subcortical regions and low for the sensory, motor and medial prefrontal cortices, and the precuneus. In order to facilitate RSN reproducibility in future studies, we provide a new freely available Consensual Atlas of REsting‐state Networks, based on the most reliable atlases.