Open AccessDefault‐mode network functional connectivity is closely related to metabolic activity
Author(s) -
Passow Susanne,
Specht Karsten,
Adamsen Tom Christian,
Biermann Martin,
Brekke Njål,
Craven Alexander Richard,
Ersland Lars,
Grüner Renate,
KlevenMadsen Nina,
Kvernenes OleHeine,
Schwarzlmüller Thomas,
Olesen Rasmus Aamand,
Hugdahl Kenneth
Publication year - 2015
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22753
Subject(s) - default mode network , neuroscience , functional magnetic resonance imaging , precuneus , glutamatergic , resting state fmri , angular gyrus , psychology , blood oxygen level dependent , superior frontal gyrus , inferior frontal gyrus , temporal lobe , middle frontal gyrus , medicine , glutamate receptor , epilepsy , receptor
Over the last decade, the brain's default‐mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more specifically, the blood‐oxygen level‐dependent (BOLD) signal, are still incompletely understood. In the present study, we combined 2‐deoxy‐2‐[ 18 F]fluoroglucose positron emission tomography (FDG‐PET), proton magnetic resonance spectroscopy ( 1 H‐MRS), and resting‐state functional magnetic resonance imaging (rs‐fMRI) to investigate more directly the association between local glucose consumption, local glutamatergic neurotransmission and DMN functional connectivity during rest. The results of the correlation analyzes using the dorsal posterior cingulate cortex (dPCC) as seed region showed spatial similarities between fluctuations in FDG‐uptake and fluctuations in BOLD signal. More specifically, in both modalities the same DMN areas in the inferior parietal lobe, angular gyrus, precuneus, middle, and medial frontal gyrus were positively correlated with the dPCC. Furthermore, we could demonstrate that local glucose consumption in the medial frontal gyrus, PCC and left angular gyrus was associated with functional connectivity within the DMN. We did not, however, find a relationship between glutamatergic neurotransmission and functional connectivity. In line with very recent findings, our results lend further support for a close association between local metabolic activity and functional connectivity and provide further insights towards a better understanding of the underlying mechanism of the BOLD signal. Hum Brain Mapp 36:2027–2038, 2015 . © 2015 Wiley Periodicals, Inc.