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Mean diffusivity of globus pallidus associated with verbal creativity measured by divergent thinking and creativity‐related temperaments in young healthy adults
Author(s) -
Takeuchi Hikaru,
Taki Yasuyuki,
Sekiguchi Atsushi,
Hashizume Hiroshi,
Nouchi Rui,
Sassa Yuko,
Kotozaki Yuka,
Miyauchi Carlos Makoto,
Yokoyama Ryoichi,
Iizuka Kunio,
Nakagawa Seishu,
Nagase Tomomi,
Kunitoki Keiko,
Kawashima Ryuta
Publication year - 2015
Publication title -
human brain mapping
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.005
H-Index - 191
eISSN - 1097-0193
pISSN - 1065-9471
DOI - 10.1002/hbm.22739
Subject(s) - globus pallidus , novelty seeking , psychology , harm avoidance , reward dependence , temperament , substantia nigra , temperament and character inventory , personality , pars compacta , developmental psychology , divergent thinking , neuroscience , dopaminergic , cognition , dopamine , basal ganglia , social psychology , central nervous system
Recent investigations revealed mean diffusivity (MD) in gray matter and white matter areas is correlated with individual cognitive differences in healthy subjects and show unique properties and sensitivity that other neuroimaging tools donot have. In this study, we tested the hypothesis that the MD in the dopaminergic system is associated with individual differences in verbal creativity measured by divergent thinking (VCDT) and novelty seeking based on prior studies suggesting associations between these and dopaminergic functions. We examined this issue in a large sample of right‐handed healthy young adults. We used analyses of MD and a psychological measure of VCDT, as well as personality measures of the Temperament and Character Inventory (TCI). Our results revealed associations between higher VCDT and lower MD in the bilateral globus pallidus. Furthermore, not only higher novelty seeking, but also lower harm avoidance, higher self‐directedness, and higher self‐transcendence were robustly associated with lower MD in the right globus pallidus, whereas higher persistence was associated with lower MD in the left globus pallidus. These personality variables were also associated with VCDT. The globus pallidus receives the dopaminergic input from the substantia nigra and plays a key role in motivation which is critically linked to dopamine. These results suggested the MD in the globus pallidus, underlie the association between VCDT and multiple personalities in TCI including novelty seeking. Hum Brain Mapp 36:1808–1827, 2015 . © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc .

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