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Premium Effects of Microglia on Neurogenesis
Sato Kaoru
Publication year2015
Publication title
Resource typeJournals
This review summarizes and organizes the literature concerning the effects of microglia on neurogenesis, particularly focusing on the subgranular zone (SGZ) of the hippocampus and subventricular zone (SVZ) of the lateral ventricles, in which the neurogenic potential is progressively restricted during the life of the organism. A comparison of microglial roles in neurogenesis in these two regions indicates that microglia regulate neurogenesis in a temporally and spatially specific manner. Microglia may also sense signals from the surrounding environment and have regulatory effects on neurogenesis. We speculate microglia function as a hub for the information obtained from the inner and outer brain regions for regulating neurogenesis. GLIA 2015;63:1394–1405
Subject(s)biology , hippocampus , immunology , inflammation , lateral ventricles , microbiology and biotechnology , microglia , neural stem cell , neurogenesis , neuroscience , stem cell , subgranular zone , subventricular zone
SCImago Journal Rank2.954

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