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A Comparison of Software Packages that Assess Linkage Using a Variance Components Approach
Author(s) -
Atkinson Elizabeth J.,
Hall Deborah,
de Andrade Mariza
Publication year - 2001
Publication title -
genetic epidemiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.301
H-Index - 98
eISSN - 1098-2272
pISSN - 0741-0395
DOI - 10.1002/gepi.2001.21.s1.s81
Subject(s) - linkage (software) , variance components , covariate , replicate , software , variance (accounting) , german , quantitative trait locus , trait , biology , genetics , heritability , chromosome , statistics , computer science , geography , mathematics , accounting , archaeology , gene , business , programming language
We report single‐point and multipoint results from three statistical genetics software packages using a variance components approach for quantitative traits. When possible, we have shown the effects of covariates. Results from GENEHUNTER, SOLAR, and ACT software packages are compared for the quantitative trait immunoglobulin E (IgE) using chromosome 5 asthma familial data from Oxfordshire (England), Perth (Australia), and Freiburg (Germany), and using the genome‐wide German data. Although few differences among variance components results for GENEHUNTER, SOLAR, and ACT were detected on a limited region of chromosome 5, these packages showed larger disagreement in the German data for chromosomes 1, 9, and 14. © 2001 Wiley‐Liss, Inc.