Open AccessA companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK 3 Physiology Working Group of the ILAE / AES Joint Translational Task Force
Author(s) -
Gorter Jan A.,
van Vliet Erwin A.,
Dedeurwaerdere Stefanie,
Buchanan Gordon F.,
Friedman Daniel,
Borges Karin,
Grabenstatter Heidi,
Lukasiuk Katarzyna,
Scharfman Helen E.,
Nehlig Astrid
Publication year - 2018
Publication title -
epilepsia open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.247
H-Index - 16
ISSN - 2470-9239
DOI - 10.1002/epi4.12261
Subject(s) - epilepsy , medicine , harmonization , task (project management) , standardization , brain function , neuroscience , comparability , translational research , bioinformatics , psychology , computer science , biology , pathology , physics , management , acoustics , economics , operating system , mathematics , combinatorics
Summary The International League Against Epilepsy/American Epilepsy Society ( ILAE / AES ) Joint Translational Task Force created the TASK 3 working groups to create common data elements ( CDE s) for various aspects of preclinical epilepsy research studies, which could help improve standardization of experimental designs . This article concerns the parameters that can be measured to assess the physiologic condition of the animals that are used to study rodent models of epilepsy. Here we discuss CDE s for physiologic parameters measured in adult rats and mice such as general health status, temperature, cardiac and respiratory function, and blood constituents. We provide detailed CDE tables and case report forms ( CRF s), and with this companion manuscript we discuss the monitoring of different aspects of physiology of the animals. The CDE s, CRF s, and companion paper are available to all researchers, and their use will benefit the harmonization and comparability of translational preclinical epilepsy research. The ultimate hope is to facilitate the development of biomarkers and new treatments for epilepsy.