Open AccessHigh‐frequency oscillations detected in EC oG recordings correlate with cavernous malformation and seizure‐free outcome in a child with focal epilepsy: A case report
Author(s) -
Liu Su,
Quach Michael M.,
Curry Daniel J.,
Ummat Monika,
Seto Elaine,
Ince Nuri F.
Publication year - 2017
Publication title -
epilepsia open
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.247
H-Index - 16
ISSN - 2470-9239
DOI - 10.1002/epi4.12056
Subject(s) - epilepsy , intractable epilepsy , hemosiderin , electroencephalography , epilepsy surgery , resection , medicine , neuroscience , psychology , audiology , anesthesia , surgery , pathology
Summary Epilepsy associated with cavernous malformation ( CM ) often requires surgical resection of seizure focus to achieve seizure‐free outcome. High‐frequency oscillations ( HFO s) in intracranial electroencephalogram ( EEG ) are reported as potential biomarkers of epileptogenic regions, but to our knowledge there are no data on the existence of HFO s in CM ‐caused epilepsy. Here we report our experience of the identification of the seizure focus in a 3‐year‐old pediatric patient with intractable epilepsy associated with CM . The electrocorticographic recordings were obtained from a 64‐contact grid over 2 days in the epilepsy monitoring unit ( EMU ). The spatial distribution of HFO s and epileptic spikes were estimated from recording segments right after the electrode placement, during sleep and awake states separately. The HFO distribution showed consistency with the perilesional region; the location of spikes varied over days and did not correlate with the lesion. The HFO spatial distribution was more compact in sleep state and pinpointed the contacts sitting on the CM border. Following the resection of the CM and the hemosiderin ring, the patient became seizure‐free. This is the first report describing HFO s in a pediatric patient with intractable epilepsy associated with CM and shows their potential in identifying the seizure focus.