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Anchoring microtubules to the centrosome is critical for cell geometry and polarity, yet the molecular mechanism remains unknown. Here we show that the conserved human  M sd1/ SSX 2I P  is required for microtubule anchoring.  hM sd1/ SSX 2I P  is delivered to the centrosome in a centriolar satellite‐dependent manner and binds the microtubule‐nucleator γ‐tubulin complex.  hM sd1/ SSX 2I P  depletion leads to disorganised interphase microtubules and misoriented mitotic spindles with reduced length and intensity. Furthermore,  hM sd1/ SSX 2I P  is essential for ciliogenesis, and during zebrafish embryogenesis, knockdown of its orthologue results in ciliary defects and disturbs left‐right asymmetry. We propose that the  M sd1 family comprises conserved microtubule‐anchoring proteins.

Msd1/ SSX 2 IP ‐dependent microtubule anchorage ensures spindle orientation and primary cilia formation