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P o PD Modified ITO Based Capacitive Immunosensor for Sulphathiazole
Author(s) -
Prusty Arun Kumar,
Bhand Sunil
Publication year - 2017
Publication title -
electroanalysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.574
H-Index - 128
eISSN - 1521-4109
pISSN - 1040-0397
DOI - 10.1002/elan.201700070
Subject(s) - dielectric spectroscopy , detection limit , materials science , indium tin oxide , capacitive sensing , biosensor , analytical chemistry (journal) , atomic force microscopy , electrochemistry , chromatography , nuclear chemistry , nanotechnology , chemistry , electrode , thin film , computer science , operating system
Abstract A capacitive immunosensor for determination of sulphathaizole (STZ) has been developed on polymer coated indium tin oxide glass chip (ITO). The immunosensor chip was fabricated by polymerizing, ortho‐ phenylenediamine ( o PD) on ITO followed by surface modification with anti‐sulphathiazole antibody. The developed immunosensor chip was characterized by using Atomic force microscopy (AFM), Cyclicvoltammetry (CV) and Electrochemical impedance spectroscopy (EIS). The capacitive measurement of the developed immunosensor was performed by using EIS in spiked drinking water and milk. The developed sensor showed liner detection range 0.1‐100 μgL −1 for STZ with a limit of detection 0.01 μgL −1 in water with recovery between 95–106 %. The biosensor showed excellent selectivity and storage stability upto 4 weeks when preserved at 4 °C.