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Evolving understanding on the aetiology of thermally provoked itch
Author(s) -
Murota H.,
Katayama I.
Publication year - 2016
Publication title -
european journal of pain
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.305
H-Index - 109
eISSN - 1532-2149
pISSN - 1090-3801
DOI - 10.1002/ejp.777
Subject(s) - transient receptor potential channel , calcitonin gene related peptide , trpv1 , burning sensation , dermatology , medicine , sensation , pathological , skin temperature , neuroscience , psychology , receptor , pathology , neuropeptide
Background and objectives Itch is one of the major symptoms in dermatology clinics, and severely impairs the quality of life. Itch is frequently produced by environmental stimuli, especially heat or warmth. Changes of temperature on the skin surface and noxious heat stimuli augment and develop itch, respectively. Thermally provoked itch is sometimes intractable with existing treatments. Data bases and data treatment Recent researches, linking heat sensation and itch, were searched in MEDLINE literature database through PubMed. Results Recent studies of the transient receptor potential cation channel subfamily vanilloid type 1 (TRPV1), the calcitonin gene‐related peptide (CGRP) and the vesicular glutamate transporter 2 (VGLUT2), which link noxious heat and itch, contribute to a much better understanding of the thermally evoked itch process. From a clinical perspective, a warm sensation is a major provocative factor for subjects with atopic dermatitis. The accumulation of artemin (also known as enovin or neublastin) in the dermis of lesional skin can possibly provide a pathological mechanism for warmth‐provoked itch. Conclusions This mini‐review describes recent results of both basic and clinical research related to thermally provoked itch.