Premium
Palladium‐Catalyzed Dearomatizing Difunctionalization of Indoles and Benzofurans
Author(s) -
Ramella Vincenzo,
He Zhiheng,
Daniliuc Constantin G.,
Studer Armido
Publication year - 2016
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201600194
Subject(s) - chemistry , palladium , catalysis , aryl , organic chemistry , combinatorial chemistry , tricyclic , alkyl
Abstract A palladium‐catalyzed dearomatizing difunctionalization of N ‐Boc‐indoles and benzofurans to give tricyclic indolines and 2,3‐dihydrobenzofurans with a fully substituted carbon center is described. Product formation occurs under mild conditions at room temperature with commercially available aryl boronic acids and 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) as a mild oxidant in good yields.