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Solid‐Supported Iodonium Salts for Fluorinations
Author(s) -
Edwards Richard,
de Vries Wilke,
Westwell Andrew D.,
Daniels Stephen,
Wirth Thomas
Publication year - 2015
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201500992
Subject(s) - synthon , chemistry , salt (chemistry) , fluoride , halogenation , combinatorial chemistry , organic chemistry , inorganic chemistry
Abstract Solid‐supported iodonium salt precursors have been prepared and used for the production of fluoroarenes. The importance of the resin functionality for the attachment of the iodonium salt moieties has been demonstrated. Furthermore, the production of new iodonium salt precursors for fluorination has been achieved by an alternative and improved method with respect to those previously described. The successful radiofluorination of a simple solid‐supported precursor with no‐carrier‐added (n.c.a.) [ 18 F]fluoride shows the suitability of the method for the production of useful PET synthons.