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Aromatic Nitrogen Donors for Efficient Copper(I)–NHC CuAAC under Reductant‐Free Conditions
Author(s) -
Teyssot MarieLaure,
Nauton Lionel,
Canet JeanLouis,
Cisnetti Federico,
Chevry Aurélien,
Gautier Arnaud
Publication year - 2010
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201000046
Subject(s) - chemistry , copper , carbene , cycloaddition , catalysis , alkyne , azide , combinatorial chemistry , nitrogen , polymer chemistry , organic chemistry , medicinal chemistry
Abstract Copper(I)‐catalysed azide–alkyne cycloaddition (CuAAC) has been successfully conducted under reductant‐free conditions. The catalytic system consisted of a combination of a copper(I)–N‐heterocyclic carbene complex and aromatic N‐donors. The catalyst is stable and can be stored, thus rendering the reaction valuable for routine use.