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Aims  The beneficial effects of  CRT  in patients with advanced heart failure, wide  QRS , and low  LVEF  have been clearly established. Nevertheless, mortality remains high in some patients. The aims of our study were to identify the predictors of mortality in patients treated with  CRT  and to design a risk score for mortality.    Methods and results  A cohort of 608 consecutive patients treated with  CRT  from 2000 to 2011 in our centre was prospectively analysed. Baseline clinical and echocardiography variables were analysed and mortality data were collected. During a mean follow‐up of 36.2 ± 29.2 months, 174 patients died: 123/174 (71%) due to cardiovascular causes, 25/174 (14%) non‐cardiac causes, and 26/174 (15%) unknown aetiology. In a multivariate analysis the predictors of mortality were  NYHA  class  IV  [hazard ratio ( HR ) 2.54, 95% confidence interval ( CI ) 1.7–3.7,  P  < 0.001], glomerular filtration rate ( GFR ) <60  mL /min/1.73 m 2  ( HR  1.61, 95%  CI  1.14–2.30,  P  = 0.008),  AF  ( HR  1.67, 95%  CI  1.19–2.3,  P  = 0.01), age ≥70 years ( HR  1.44, (95%  CI  1.04–2.00,  P  = 0.02), and  LVEF  <22% ( HR  1.83, 95%  CI  1.33–2.52,  P  ≤ 0.001). The  EAARN  score ( EF , Age,  AF , Renal dysfunction,  NYHA  class  IV ) summarizes the predictors. Each additional predictor increased the mortality: one predictor,  HR  3.28 (95%  CI  1.37–7.8,  P  = 0.008); two,  HR  5.23 (95%  CI  2.24–12.10,  P  < 0.001); three,  HR  9.63 (95%  CI  4.1–22.60,  P  < 0.001); and four or more,  HR  14.38 (95%  CI  5.8–35.65,  P  < 0.001).    Conclusion  The predictors of mortality have a significant add‐on predictive effect on mortality. The  EAARN  score could be useful to stratify the prognosis of  CRT  patients.

EAARN score, a predictive score for mortality in patients receiving cardiac resynchronization therapy based on pre‐implantation risk factors