Open AccessIndependent link between peripheral artery disease and muscle wasting in patients with heart failure
Author(s) -
Ohori Katsuhiko,
Yano Toshiyuki,
Katano Satoshi,
Kouzu Hidemichi,
Inoue Takuya,
Takamura Yuhei,
Nagaoka Ryohei,
Ishigo Tomoyuki,
Koyama Masayuki,
Nagano Nobutaka,
Fujito Takefumi,
Nishikawa Ryo,
Miura Tetsuji
Publication year - 2020
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.12951
Subject(s) - wasting , medicine , diabetes mellitus , cardiology , heart failure , quartile , sarcopenia , logistic regression , cachexia , endocrinology , confidence interval , cancer
Aims A high prevalence of muscle wasting, that is, reduction in muscle mass, in patients with peripheral artery disease (PAD) and heart failure (HF) has been reported. However, whether the association between PAD and muscle wasting is independent of shared risk factors such as diabetes mellitus has not been examined. Methods and results We retrospectively enrolled 440 HF patients (mean age, 74 years; inter‐quartile range, 64–82 years; 52% male). Muscle wasting was defined as an appendicular skeletal muscle mass index (ASMI) of <7.0 kg/m 2 in men and <5.4 kg/m 2 in women. PAD was defined as an ankle brachial index (ABI) of <0.9 in either leg. The prevalence of PAD in HF patients was 21%. ASMI was positively correlated with ABI in HF patients. In multivariate logistic regression analysis, ASMI and muscle wasting were selected as independent explanatory factors of the presence of PAD after adjustment for age, sex, diabetes mellitus, hypertension, dyslipidaemia, estimated glomerular filtration rate, and smoking status, established risk factors of atherosclerosis. In propensity score‐matched analysis, frequency of muscle wasting was higher in patients with PAD than in patients with an ABI of ≧1.1 (72.1% vs. 52.5%, P = 0.04). Conclusions The results suggest that there is an independent link between PAD and muscle wasting in HF patients.