Open AccessAlteration of medical therapy in patients with heart failure relative to change in symptom severity
Author(s) -
Ibrahim Nasrien E.,
Song Yang,
Can Christopher P.,
Doros Gheorghe,
Russo Patricia,
Ponirakis Angelo,
Alexanian Claire,
Januzzi James L.
Publication year - 2019
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.12480
Subject(s) - medicine , heart failure , valsartan , observational study , context (archaeology) , guideline , ambulatory , ejection fraction , medical therapy , intensive care medicine , cardiology , emergency medicine , blood pressure , paleontology , pathology , biology
Abstract In this observational analysis from the Practice Innovation and Clinical Excellence Registry®, we examined changes in guideline‐directed medical therapies relative to changes in symptom severity in ambulatory patients with heart failure with reduced ejection fraction, finding change in medication more often occurring when patients were changing their New York Heart Association symptom severity, rather than during periods of stable symptoms. Additionally, despite being available for a year during the time of our analysis, the use of sacubitril/valsartan was extremely low, and most often added in the context of worsening symptoms, not how this drug was studied and not how the guidelines articulate its use.