Open AccessACE inhibitor‐associated intestinal angioedema in orthotopic heart transplantation
Author(s) -
Srinivasan Dushyanth,
Strohbehn Garth W.,
Cascino Thomas
Publication year - 2017
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.12161
Subject(s) - medicine , angioedema , immunosuppression , ace inhibitor , heart transplantation , tacrolimus , angiotensin converting enzyme , heart failure , sirolimus , transplantation , lisinopril , prednisone , cardiology , surgery , blood pressure
Angiotensin‐converting enzyme inhibitor induced angioedema commonly involves the head and neck area. We report a case of angiotensin‐converting enzyme inhibitor induced intestinal angioedema in a heart transplant recipient on mTOR immunosuppression. A 36‐year‐old Caucasian woman with history of heart transplantation on sirolimus, tacrolimus and prednisone presented to the Emergency Department with abdominal pain, one day following lisinopril initiation. A computer tomography scan demonstrated diffuse bowel wall thickening consistent with pancolitis and edema. She was subsequently diagnosed with angiotensin‐converting enzyme inhibitor induced angioedema. Patients on mTOR immunosuppression are at higher risk for this potentially life‐threatening side effect. Knowledge of this interaction is critical for providers prescribing mTOR agents.