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Impaired myocardial relaxation with exercise determines peak aerobic exercise capacity in heart failure with preserved ejection fraction
Author(s) -
Trankle Cory,
Canada Justin M.,
Buckley Leo,
Carbone Salvatore,
Dixon Dave,
Arena Ross,
Van Tassell Benjamin,
Abbate Antonio
Publication year - 2017
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.12147
Subject(s) - medicine , cardiology , heart failure , exercise intolerance , vo2 max , heart failure with preserved ejection fraction , ejection fraction , diastole , aerobic exercise , stroke volume , heart rate , blood pressure
Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity due to shortness of breath and/or fatigue. Assessment of diastolic dysfunction at rest and with exercise may provide insight into the pathophysiology of exercise intolerance in HFpEF. Aims To measure echocardio‐Doppler‐derived parameters of diastolic function as they relate to various indices of aerobic exercise capacity in HFpEF. Methods We selected 16 subjects with clinically stable HFpEF, no evidence of volume overload, but impaired functional capacity by cardiopulmonary exercise testing [peak oxygen consumption (VO 2 )]. We measured the transmitral E and A flow velocities, E/A ratio, and E deceleration time (DT) and tissue Doppler E′ velocity. We also indexed the E′ to the DT, as additional measure of impaired relaxation (E′ DT ), and calculated the diastolic functional reserve index (DFRI), as the product of E′ at rest and change in E′ with exercise. Results E′ velocity, at rest and peak exercise, as well as the DFRI positively correlated with peak VO 2 , whereas DT, E′ DT , and E/E′ with exercise inversely correlated with peak VO 2 . Of note, the E′ DT at rest also significantly predicted E′ velocity at peak exercise ( R  = +0.81, P  < 0.001). Exercise E′ was the only independent predictor of peak VO 2 at multivariable analysis ( R  = +0.67, P  = 0.005). Conclusions The E′ velocity at peak exercise is a strong and independent predictor of aerobic exercise capacity as measured by peak VO 2 in patients with HFpEF, providing the link between abnormal myocardial relaxation with exercise and impaired aerobic exercise capacity in HFpEF.

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